6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester
6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester
CAS: 155377-05-2
Molecular Formula: C8H6F3NO2
6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester - Names and Identifiers
6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester - Physico-chemical Properties
| Molecular Formula | C8H6F3NO2 |
| Molar Mass | 205.13 |
| Density | 1.331±0.06 g/cm3(Predicted) |
| Boling Point | 232.6±40.0 °C(Predicted) |
| Flash Point | 94.5°C |
| Vapor Presure | 0.0584mmHg at 25°C |
| pKa | -0.97±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.446 |
6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester - Introduction
acid methyl ester, chemical formula C8H4F3NO2, is an organic compound.
Nature:
1. Appearance: acid methyl ester is a colorless liquid.
2. Melting Point: About -30 ℃.
3. Boiling point: About 140-142 ℃.
4. Density: about 1.366 g/cm.
5. Solubility: Soluble in organic solvents, such as ethanol and dimethylformamide.
Use:
1. acid methyl ester is commonly used as a substrate or reagent in organic synthesis.
2. It can be used to synthesize other organic compounds, such as biologically active molecules and drugs.
3. Can also be used as a catalyst and solvent.
Method:
acid methyl ester can be prepared by the following steps:
1. Pyridine and tert-butyl disilyl alcohol are heated to react in a solvent to generate tert-butyl disilyl pyridine.
2. The tert-butyl dimethylsilyl pyridine is reacted with trifluoromethylcuprous iodide under the protection of nitrogen to generate 6-trifluoromethylpyridine-2-methanol.
3. Finally, 6-trifluoromethylpyridine-2-methanol is reacted with methyl formate to generate acid methyl ester.
Safety Information:
1. acid methyl ester is a common compound in organic synthesis, but it is an organic solvent and has a certain volatility, so you should pay attention to good ventilation when using it.
2. During use, avoid contact with skin and eyes, and make sure to use personal protective equipment such as protective gloves and safety glasses.
3. The compound may be harmful to the environment, and care should be taken to avoid it from entering the environment.
4. When storing and handling the compound, follow the relevant safety procedures and store it in a sealed container, away from fire and oxidizing agents.
Nature:
1. Appearance: acid methyl ester is a colorless liquid.
2. Melting Point: About -30 ℃.
3. Boiling point: About 140-142 ℃.
4. Density: about 1.366 g/cm.
5. Solubility: Soluble in organic solvents, such as ethanol and dimethylformamide.
Use:
1. acid methyl ester is commonly used as a substrate or reagent in organic synthesis.
2. It can be used to synthesize other organic compounds, such as biologically active molecules and drugs.
3. Can also be used as a catalyst and solvent.
Method:
acid methyl ester can be prepared by the following steps:
1. Pyridine and tert-butyl disilyl alcohol are heated to react in a solvent to generate tert-butyl disilyl pyridine.
2. The tert-butyl dimethylsilyl pyridine is reacted with trifluoromethylcuprous iodide under the protection of nitrogen to generate 6-trifluoromethylpyridine-2-methanol.
3. Finally, 6-trifluoromethylpyridine-2-methanol is reacted with methyl formate to generate acid methyl ester.
Safety Information:
1. acid methyl ester is a common compound in organic synthesis, but it is an organic solvent and has a certain volatility, so you should pay attention to good ventilation when using it.
2. During use, avoid contact with skin and eyes, and make sure to use personal protective equipment such as protective gloves and safety glasses.
3. The compound may be harmful to the environment, and care should be taken to avoid it from entering the environment.
4. When storing and handling the compound, follow the relevant safety procedures and store it in a sealed container, away from fire and oxidizing agents.
Last Update：2024-04-09 21:00:56
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CAS: 155377-05-2
Tel: 18301782025
Email: 3008007409@qq.com
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Product Name: 6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester Request for quotation
CAS: 155377-05-2
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Wechat: 15387090420
CAS: 155377-05-2
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
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